| Bioactivity | HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy[1]. | ||||||||||||
| In Vivo | HBED monohydrochloride dihydrate 在不同的给药方式下，产生的活性不同。HBED 以 81、162 和 324 μMol/kg 的剂量，口服给药后不会产生显著效果。而以 162 和 324 μMol/kg 的剂量，在皮下给药后，提高了净铁排泄量[1]。 | ||||||||||||
| Name | HBED dihydrochloride | ||||||||||||
| CAS | 35369-53-0 | ||||||||||||
| Formula | C20H26Cl2N2O6 | ||||||||||||
| Molar Mass | 461.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Bergeron RJ, et al. HBED: the continuing development of a potential alternative to deferoxamine for iron-chelating therapy. Blood. 1999 Jan 1;93(1):370-5. |
HBED dihydrochloride
CAS: 35369-53-0 F: C20H26Cl2N2O6 W: 461.34
HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-b
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