| Bioactivity | H1k, a Eudistomin Y derivative, is a lysosome-targeted antiproliferation agent. H1k increases the autophagy signal and downregulate the expression of cyclin-dependent kinase (CDK1) and cyclin B1 which principally regulated the G2-M transition. H1k can be used in research of cancer[1]. |
| Invitro | H1k (72 h) 对 LS-180、HepG-2、SGC-7901、A549 和 MDA-MB-231 细胞具有抗增殖活性，IC50 值分别为 2.9、9.6、12.1、14.8 和 20.5 μM[1]。H1k (0-50 μM; 24 h) 以剂量依赖性方式触发 MDA-MB-231 和 SGC-7901 细胞明显的 G2-M 停滞[1]。H1k (0-20 μM; 6 h; MDA-MB-231 细胞) 诱导自噬发挥其抗增殖活性，溶酶体是其功能靶点[1]。 Cell Cycle Analysis[1] Cell Line: |
| Name | H1k |
| Formula | C26H22N2O2 |
| Molar Mass | 394.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang G, et, al. Design, synthesis, and discovery of Eudistomin Y derivatives as lysosome-targeted antiproliferation agents. Eur J Med Chem. 2023 Mar 15;250:115193. |