Guanethidine sesquisulfate_product_DataBase

Bioactivity	Guanethidine sesquisulfate, an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sesquisulfate enters noradrenergic nerve terminals by the neuronal amine carrier[1][2].
In Vivo	Guanethidine sesquisulfate（5-40 mg/kg；腹膜内注射；每日；4-28 天；雄性 Wistar 大鼠）以 40 mg/kg 治疗 28 天会导致不完全交感神经切除，并伴有对去甲肾上腺素的部分不可逆超敏反应，而 5 mg/kg 不会引起组织学或永久性血流动力学变化[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	60-02-6
Formula	C10H22N4.1/2H2O4S
Molar Mass	247.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mitchell JR, et al. Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA. 1967 Dec 4;202(10):973-6. [2]. Nielsen GD. Guanethidine induced sympathectomy in the adult rat. I. Functional effects following subacute administration. Acta Pharmacol Toxicol (Copenh). 1977 Sep;41(3):203-8.

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