| Bioactivity | Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1]. | ||||||||||||
| Invitro | Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1]. | ||||||||||||
| Name | Glycocholic acid | ||||||||||||
| CAS | 475-31-0 | ||||||||||||
| Formula | C26H43NO6 | ||||||||||||
| Molar Mass | 465.62 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Glycocholic acid
CAS: 475-31-0 F: C26H43NO6 W: 465.62
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resista
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