| Bioactivity | Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity[1][2]. |
| Invitro | Glufosinate (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2].Glufosinate (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2].Glufosinate impairs ependymal cell capability to synthetize cilia[2]. |
| In Vivo | Glufosinate (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3].The Elimination of Glufosinate (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3]. |
| Name | Glufosinate |
| CAS | 51276-47-2 |
| Formula | C5H12NO4P |
| Molar Mass | 181.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945. [2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163. [3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49. |
Glufosinate
CAS: 51276-47-2 F: C5H12NO4P W: 181.13
Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-ph
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