Glucagon (22-29)_product_DataBase

Bioactivity	Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca2+ pump in liver plasma membranes independently of adenylate cyclase activation[1][2].
Invitro	Glucagon (22-29) produces only a 5-15% maximal inhibition of (Ca2+-Mg2+) ATPase, with a low potency (Ki=1 μM), similar to that of native glucagon[1].Glucagon (22-29) (10 nM) evokes an early small decrease of cell contraction when added alone and an 18% significant positive inotropic effect when added in combination with 30 nM glucagon. Glucagon (22-29) thus appears to act as a partial agonist of miniglucagon[2].Glucagon (22-29) consists of the COOH-terminal part of miniglucagon but lacks the three Ala1g-Gln20-Asp21 residues[2].
Name	Glucagon (22-29)
CAS	32204-93-6
Shortening	FVQWLMNT
Formula	C49H71N11O12S
Molar Mass	1038.22
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mallat A, et al. A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon. Nature. 1987 Feb 12-18;325(6105):620-2. [2]. Pavoine C, et al. Miniglucagon [glucagon-(19-29)] is a component of the positive inotropic effect of glucagon. Am J Physiol. 1991 May;260(5 Pt 1):C993-9.

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