| Bioactivity | Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity[1]. |
| Target | IC50: 2.76 μΜ (tubulin polymerization) |
| Invitro | Glochidiol (1-8 μM; 48 h) 对肺癌细胞系显示出强效的抗增殖活性，且呈浓度依赖性[1]。Glochidiol 通过靶向秋水仙碱结合位点与微管蛋白相互作用[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Glochidiol (60 mg/kg/day; i.g.; 21 days) 在裸鼠中有效抑制肺癌 HCC-44 异种移植瘤生长[1]。 Animal Model: |
| Name | Glochidiol |
| CAS | 6610-56-6 |
| Formula | C30H50O2 |
| Molar Mass | 442.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen H, et al. Glochidiol, a natural triterpenoid, exerts its anti-cancer effects by targeting the colchicine binding site of tubulin. Invest New Drugs. 2021 Apr;39(2):578-586. |