Gd-NMC-3_product_DataBase

Bioactivity	Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential[1]. Storage: protect from light.
Invitro	Gd-NMC-3 shows the maximum excitation wavelength and emission wavelength are 755 and 792 nm, respectively. Both wavelengths are located in the near-infrared region[1].Gd-NMC-3 acts as a bimodal imaging molecule, can be accumulated in tumor sites[1].Gd-NMC-3 (50 μM; 24 h) can be internalized into cancer cells by OATPs and NTCP, indicating an excellent specificity to tumor tissues[1].Gd-NMC-3 (6.25-800 μM, 24 h) exhibits significant fluorescence accumulation (with the optimal concentration of 100, 200 μM) and reasonable relaxation property (11.64 M/m/s) in tumors[1].Gd-NMC-3 (6.25-100 μM, 48 h) displays low cytotoxicity and good biocompatibility[1]. Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Gd-NMC-3 (20 mg/kg; i.v.) holds an excellent tumor targeting ability, shows high resolution and sensitivity and provides real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors[1]. Animal Model:
Name	Gd-NMC-3
CAS	2678579-76-3
Formula	C77H116Gd2N14O22S2
Molar Mass	1968.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li Q, et al. Tumor-Targeting NIRF/MR Dual-Modal Molecular Imaging Probe for Surgery Navigation. Anal Chem. 2022 Aug 3.

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Gd-NMC-3

CAS: 2678579-76-3 F: C77H116Gd2N14O22S2 W: 1968.46