| Bioactivity | Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2]. | ||||||||||||
| Invitro | Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].Ganoderic acid D (1-50 μM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner[2]. Ganoderic acid D (10, 50 μM; 24, 48 hours) induces G2/M phase arrest[2]. Ganoderic acid D (10, 50 μM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells[2]. Ganoderic acid D (10 μM; 48 hours) up-regulates 14-3-3E and PRDX3[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Ganoderic acid D | ||||||||||||
| CAS | 108340-60-9 | ||||||||||||
| Formula | C30H42O7 | ||||||||||||
| Molar Mass | 514.65 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Ganoderic acid D
CAS: 108340-60-9 F: C30H42O7 W: 514.65
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Gano
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