Gadobutrol_product_DataBase

Bioactivity

Gadobutrol (Gd-DO3A-butrol; ZK 135079) is a nonionic paramagnetic macrocyclic gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI)[1].

Invitro

Gadobutrol leads to a gradual decrease in cell density with increasing concentration under neutron irradiation[1]. Cell Viability Assay[1] Cell Line:

In Vivo

Gadobutrol (intravenous injection, 200 mM, once, a week) can significantly enhance intracerebroventricular cell signaling in female C57BL/6 N mice[2]. Animal Model:

Name

Gadobutrol

CAS

770691-21-9

Formula

C18H31GdN4O9

Molar Mass

604.71

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. B Hofmann, et al. Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent Gadobutrol. Invest Radiol. 1999 Feb;34(2):126-33. [2]. Takashi Watanabe, et al. Gadobutrol enhances T1-weighted MRI of nerve cells. Toxicol Lett. 2019 Jun 15;308:17-23. [3]. Cheng KT. Gadobutrol. Molecular Imaging and Contrast Agent Database (MICAD)

PeptideDB

Gadobutrol

CAS: 770691-21-9 F: C18H31GdN4O9 W: 604.71