Fsh receptor-binding inhibitor fragment(bi-10)_product_DataBase

Bioactivity	FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries[1].
In Vivo	FSH receptor-binding inhibitor fragment(bi-10) (10, 20, 30, 40 mg/kg; 肌肉注射; 每天1次; 连续5天) 在大剂量 (30 mg/kg-40 mg/kg) 可抑制卵巢和卵泡发育，降低卵巢中 ERβ 和 FSHR mRNA 和蛋白质的表达水平，抑制 E2 的产生[1]。 Animal Model:
Name	Fsh receptor-binding inhibitor fragment(bi-10)
CAS	163973-98-6
Sequence	Thr-Glu-Asn-Leu-Glu-Pro-Asn-Gly-Glu-Gly-NH2
Shortening	TENLEPNGEG-NH2
Formula	C42H67N13O19
Molar Mass	1058.06
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gong Zhuandi, et al. FSH receptor binding inhibitor restrains follicular development and possibly attenuates carcinogenesis of ovarian cancer through down-regulating expression levels of FSHR and ERβ in normal ovarian tissues. Gene. 2018 Aug 20;668:174-181.

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