| Bioactivity | Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1]. | ||||||||||||
| Invitro | Formononetin is one of the major isoflavonoid constituents isolated from Astragalus membranaceus and has been demonstrated diverse pharmacological benefits. Formononetin possesses anti-angiogenic activity in human colon cancer cells. Formononetin also promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells[1]. Formononetin (25 to 150 μM) markedly decreases the proliferation of endothelial cells stimulated by FGF2[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Formononetin | ||||||||||||
| CAS | 485-72-3 | ||||||||||||
| Formula | C16H12O4 | ||||||||||||
| Molar Mass | 268.26 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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