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| Bioactivity |
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1]. |
| Invitro |
Formononetin is one of the major isoflavonoid constituents isolated from Astragalus membranaceus and has been demonstrated diverse pharmacological benefits. Formononetin possesses anti-angiogenic activity in human colon cancer cells. Formononetin also promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells[1]. Formononetin (25 to 150 μM) markedly decreases the proliferation of endothelial cells stimulated by FGF2[1]. Cell Viability Assay[1] Cell Line: |
| Name |
Formononetin |
| CAS |
485-72-3 |
| Formula |
C16H12O4 |
| Molar Mass |
268.26 |
| Transport |
Room temperature in continental US; may vary elsewhere. |
| Storage |
| Powder |
-20°C |
3 years |
|
4°C |
2 years |
| In solvent |
-80°C |
6 months |
|
-20°C |
1 month |
|
