| Bioactivity | Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity[1]. | ||||||||||||
| Invitro | Filanesib induces mitotic arrest in multiple cell lines[1].Filanesib exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors, with EC50s between 0.4 nM and 14.4 nM[1].Filanesib (0.001-0.1 nM; 36 hours) induces apoptosis in a dose-dependent manner in HeLa cells[1].Filanesib (3.13-6.25 nM; 44 hours) causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells[1].Filanesib potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells[2].Filanesib (3 μM; 6-24 hours) is able to induce caspase-2 activation[3].Filanesib (0.003-3 μM; 24-48 hours) is cytotoxic in Type II EOC cells[3]. Apoptosis Analysis[1] Cell Line: | ||||||||||||
| Name | Filanesib | ||||||||||||
| CAS | 885060-09-3 | ||||||||||||
| Formula | C20H22F2N4O2S | ||||||||||||
| Molar Mass | 420.48 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Filanesib
CAS: 885060-09-3 F: C20H22F2N4O2S W: 420.48
Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for
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