| Bioactivity | Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research[1][2][3]. | ||||||||||||
| In Vivo | Fenclonine (intraperitoneal injection; 100 mg/kg; once daily; 3 d) treatment can inhibit Morphine-induced anti-nociceptive activity[2].Fenclonine (intraperitoneal injection; 300 mg/kg; once daily; 3 d) pretreatment completely abolishes the effects of a 50 mg/kg dose of Paracetamol[3]. Animal Model: | ||||||||||||
| Name | Fenclonine | ||||||||||||
| CAS | 7424-00-2 | ||||||||||||
| Formula | C9H10ClNO2 | ||||||||||||
| Molar Mass | 199.63 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21(2 Suppl):24S-27S. [2]. A K Sanyal, et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun;4(3):247-55. [3]. Shyamshree S S Manna, et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr;26(3):268-81. |