| Bioactivity | Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754). Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC50s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer[1]. |
| Invitro | Farnesyl thiosalicylic acid amide (50 μM, 24 h) 降低 Panc-1 和 U87 细胞中总 Ras-GTP 和 K-Ras-GTP 的水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Farnesyl thiosalicylic acid amide 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Farnesyl thiosalicylic acid amide (100 mg/kg, 灌胃, 一次) 抑制 Panc-1 裸鼠模型中肿瘤生长[1]。Farnesyl thiosalicylic acid amide (100 mg/kg, 口服, 一天两次, 14 天) 抑制 U87 裸鼠模型中肿瘤生长[1]。药代动力学分析[1]Route |
| CAS | 1092521-74-8 |
| Formula | C22H31NOS |
| Molar Mass | 357.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Goldberg L, et al. New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models. J Med Chem. 2009 Jan 8;52(1):197-205. |