FTY720 (S)-Phosphate_product_DataBase

Bioactivity

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

Target

S1PR1

Invitro

FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 µM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 µM) also reduces β-arrestin recruitment to S1PR1[1].

In Vivo

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice[1].

Name

FTY720 (S)-Phosphate

CAS

402616-26-6

Formula

C19H34NO5P

Molar Mass

387.45

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

Reference

[1]. Wang L, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42(3):e189-99. [2]. Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345.

PeptideDB

FTY720 (S)-Phosphate

CAS: 402616-26-6 F: C19H34NO5P W: 387.45