FPR2 agonist 2_product_DataBase

Bioactivity	FPR2 agonist 2 is a potent and permeates the blood−brain barrier FPR2 agonist with an EC50 of 0.13 µM, 1.1 µM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity[1].
Target	EC50: 0.13 µM (FPR2); 1.1 µM (FPR1)
Invitro	FPR2 agonist 2 (compound (S)-11l) (1-100 µM; 48 h) exhibits low cytotoxicity with an EC50 value of 20.8 µM in N9 cells[1].FPR2 agonist 2 (FPR1/FPR2 HL60 cells) shows agonist activity with EC50s of 0.13 µM, 1.1 µM (IC50s of 0.085 µM, Not determined) for FPR2 and FPR1, respectively[1].FPR2 agonist 2 (0.1 µM) effectively blocks LPS-induced cell death and NO production and effectively suppresses the effect of LPS stimulation[1].FPR2 agonist 2 (0.1 µM) counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity[1]. Cell Viability Assay[1] Cell Line:
In Vivo	FPR2 agonist 2 (1 mg/kg for i.v.; 10 mg/kg for i.p.) shows the ability to permeate the blood−brain barrier and to accumulate in the brain[1]. Animal Model:
Name	FPR2 agonist 2
CAS	2829263-20-7
Formula	C25H20F2N4O2
Molar Mass	446.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mastromarino M, et al. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders. J Med Chem. 2022; 65(6):5004-5028.

PeptideDB

FPR2 agonist 2

CAS: 2829263-20-7 F: C25H20F2N4O2 W: 446.45