| Bioactivity | FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor[1][2]. FOY 251 inhibits SARS-CoV-2 infection in cells assay[1][3]. |
| Target | Proteinase |
| Invitro | FOY-251 represents a dose-dependent inhibition of equivalent current in M-1 cells[2].FOY-251 inhibits the proteolytic activity of prostasin[2]. |
| Name | FOY 251 |
| CAS | 71079-09-9 |
| Formula | C17H19N3O7S |
| Molar Mass | 409.41 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6. [2]. Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9. [3]. Markus Hoffmann, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020 Aug 5;2020.08.05.237651. |