FEMA 4774_product_DataBase

Bioactivity	FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer[1].
Invitro	FEMA 4774 (0-50 μM) induces a dose-dependent decrease in the EC50 value of sucrose and significantly enhances the affinity of sucrose for its binding site with an α (effect of modulator on agonist affinity) value of 30 in the human sweet receptor cells[1].
In Vivo	FEMA 4774 (S9632) (oral gavage, 500-2000 mg/kg) does not cause a dose-dependent increase in polychromatic erythrocytes and induces micronuclei formation at dose levels up to 2000 mg/kg in Swiss albino (CD-1) mice[2].The pharmacokinetic parameters of FEMA 4774 (S9632) in Male and Female Sprague-Dawley Rats Route
Name	FEMA 4774
CAS	1359963-68-0
Formula	C19H25N3O4
Molar Mass	359.42
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Guy Servant, et al. The function and allosteric control of the human sweet taste receptor. Adv Pharmacol. 2020;88:59-82. [2]. Amy J Arthur, et al. Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid. Toxicol Rep. 2015 Sep 3;2:1255-1264.

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