| Bioactivity | Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1]. | |||||||||
| In Vivo | Ezurpimtrostat hydrochloride (compound 2-3) (15 mg/kg/day, PO, for 6 weeks) significantly reduces the area of liver fibrosis and the level of collagen fibers deposition (by 41.0%) in DEN cirrhotic rat model[1]. | |||||||||
| Name | Ezurpimtrostat hydrochloride | |||||||||
| CAS | 1914148-73-4 | |||||||||
| Formula | C25H32Cl2N4 | |||||||||
| Molar Mass | 459.45 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Philippe Halfon, et al. Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases. EP3620164A1. |
Ezurpimtrostat hydrochloride
CAS: 1914148-73-4 F: C25H32Cl2N4 W: 459.45
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochlor
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