| Bioactivity | Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3]. |
| Invitro | Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。 Cell Migration Assay [1] Cell Line: |
| In Vivo | 在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。 Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）治疗使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。 Animal Model: |
| Name | Euxanthone |
| CAS | 529-61-3 |
| Formula | C13H8O4 |
| Molar Mass | 228.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. [2]. Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. [3]. aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523. |