| Bioactivity | Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs[1]. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs)[2]. | ||||||||||||
| Invitro | Etonogestrel inhibits fertility by inhibiting the release of luteinizing hormone (LH), one of the reproductive hormones important in ovulation[1].Etonogestrel also increases the viscosity of cervical mucus, which hinders the passage of spermatozoa and alters the lining of the uterus to prevent implantation of a fertilized egg into the endometrium[1].Etonogestrel, a progestin, is a substrate of the CYP 3A4 oxidase system[1].Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs)[2]. Western Blot Analysis[2] Cell Line: | ||||||||||||
| Name | Etonogestrel | ||||||||||||
| CAS | 54048-10-1 | ||||||||||||
| Formula | C22H28O2 | ||||||||||||
| Molar Mass | 324.46 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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