Endothelin-1 (1-31) (Human)_product_DataBase

Bioactivity	Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase[1].
Invitro	Endothelin-1 (1-31) (Human) (100 pM-100 nM; 24 h) 诱导人系膜细胞增殖[2]。Endothelin-1 (1-31) (Human) (100 nM; 0-10 min) 在人系膜细胞中诱导 ERK 激活[2]。 Cell Proliferation Assay[2] Cell Line:
In Vivo	ET-1 (1-31) (100 nM; single dose) 诱导小鼠肠系膜动脉收缩。收缩可能是由 ETA 受体介导的，并可能随着年龄的增长而增加。在目前的慢性糖尿病的情况下，男性和女性之间存在明显差异[1]。 Animal Model:
Name	Endothelin-1 (1-31) (Human)
CAS	133972-52-8
Sequence	Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)
Shortening	CSCSSLMDKECVYFCHLDIIWVNTPEHVVPY (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)
Formula	C162H236N38O47S5
Molar Mass	3628.16
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Matsumoto T, et al. Gender differences in vascular reactivity to endothelin-1 (1-31) in mesenteric arteries from diabetic mice. Peptides. 2008 Aug;29(8):1338-46. [2]. Yoshizumi M, et al. Effect of endothelin-1 (1-31) on human mesangial cell proliferation. Jpn J Pharmacol. 2000 Oct;84(2):146-55.

PeptideDB