| Bioactivity | Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[1]. |
| In Vivo | Eletriptan (10, 30, 100, 300 and 1000 µg/kg; i.v.) reduces total carotid blood flow in anaesthetised pigs by selectively reducing carotid arteriovenous anastomotic blood flow and increasing nutrient blood flow within the carotid vascular bed[2]. |
| Name | Eletriptan |
| CAS | 143322-58-1 |
| Formula | C22H26N2O2S |
| Molar Mass | 382.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66(8):1129-49. [2]. Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):212-9. |
Eletriptan
CAS: 143322-58-1 F: C22H26N2O2S W: 382.52
Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi va
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