| Bioactivity | Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease[1][2]. | ||||||
| Invitro | Dynorphin A (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death[3].dynorphin A (33 μM, 4 h) elevates [Ca2+]i and causes a significant loss of neurons[4].dynorphin A (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe[5]. Cell Viability Assay[3] Cell Line: | ||||||
| Name | Dynorphin A | ||||||
| CAS | 80448-90-4 | ||||||
| Formula | C99H155N31O23 | ||||||
| Molar Mass | 2147.48 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Dynorphin A
CAS: 80448-90-4 F: C99H155N31O23 W: 2147.48
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS)
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