| Bioactivity | Dithranol (Anthralin) is an anthraquinone derivative, with potent anti-psoriatic effects. Dithranol can inhibit DNA replication and repair[1][2]. | ||||||||||||
| Invitro | Dithranol (1.1 μM) inhibits replication in T98G cells by 50%[2].Dithranol (0.1-0.5 μg/mL; 2-4 hours) increases the mRNA production of interleukin-10 receptors in a concentration dependent manner in HaCaT cells[3]. RT-PCR[3] Cell Line: | ||||||||||||
| Name | Dithranol | ||||||||||||
| CAS | 1143-38-0 | ||||||||||||
| Formula | C14H10O3 | ||||||||||||
| Molar Mass | 226.23 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. L Kemény , et al. Dithranol: a review of the mechanism of action in the treatment of psoriasis vulgaris. Skin Pharmacol. 1990;3(1):1-20. [2]. J M Clark, et al. Inhibition of DNA replication and repair by anthralin or danthron in cultured human cells. J Invest Dermatol. 1982 Jul;79(1):18-22. [3]. A Farkas, et al. Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT. Inflamm Res. 2001 Jan;50(1):44-9. |