| Bioactivity | Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule[1]. |
| Target | IC50: 0.07 μM (carbonic anhydrase) |
| In Vivo | Disulfamide (intraperitoneal injection, 200 mg/kg, once) has potential blood glucose raising properties in male Wistar rats[2]. Animal Model: |
| Name | Disulfamide |
| CAS | 671-88-5 |
| Formula | C7H9ClN2O4S2 |
| Molar Mass | 284.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. CT Supuran, et al. Carbonic anhydrase inhibitors: Synthesis and inhibitory properties of 1,3,4-thiadiazole-2,5-bissulfonamide. European Journal of Medicinal Chemistry,Volume 31, Issue 11, 1996, Pages 843-846. [2]. J M Foy, et al. Acute diuretic induced hyperglycaemia in rats. Life Sci. 1967 May 1;6(9):897-902. |
Disulfamide
CAS: 671-88-5 F: C7H9ClN2O4S2 W: 284.74
Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide l
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