| Bioactivity | Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) is also a PI3K inhibitor and an apoptosis inducer[1][2][3][4][5]. | ||||||
| Invitro | Disitertide (P144, 100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells[2]. Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance[3].Disitertide (10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines[5]. Western Blot Analysis[2] Cell Line: | ||||||
| Name | Disitertide | ||||||
| CAS | 272105-42-7 | ||||||
| Shortening | TSLDASIIWAMMQN | ||||||
| Formula | C68H109N17O22S2 | ||||||
| Molar Mass | 1580.82 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
Disitertide
CAS: 272105-42-7 F: C68H109N17O22S2 W: 1580.82
Disitertide (P144) is a peptidictransforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the
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