| Bioactivity | Dihydrostreptomycin (DHSM) is an antibiotic that exhibits resistance to penicillin in strains of Pseudomonas lachrymans. Studies have shown that these strains can inactivate DHSM using a cell-free system in the presence of disodium adenosine triphosphate. The inactivated DHSM can be regenerated by alkaline phosphatase but not by phosphodiesterase. The structure of the inactivated DHSM has been determined by methods such as proton magnetic resonance imaging, and it was found that the hydroxyl group at the C-3 position of DHSM in its chemical structure is phosphorylated by the enzyme. Therefore, the study suggests that ATP:aminoglycoside 3"-phosphotransferase plays a role in DHSM resistance in Pseudomonas lachrymans N-7641[1]. |
| CAS | 128-46-1 |
| Formula | C23H45N7O12 |
| Molar Mass | 611.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. YANO H, et al. On the enzymic inactivation of dihydrostreptomycin by pseudomonas lachrymans, cucumber angular leaf spot bacterium isolation and structural resolution of the inactivated product[J]. Japanese Journal of Phytopathology, 1978, 44(4): 413-419. |
Dihydrostreptomycin
CAS: 128-46-1 F: C23H45N7O12 W: 611.64
Dihydrostreptomycin (DHSM) is an antibiotic that exhibits resistance to penicillin in strains of Pseudomonas lachrymans.
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