| Bioactivity | Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells[1]. | ||||||||||||
| Name | Diethyl maleate | ||||||||||||
| CAS | 141-05-9 | ||||||||||||
| Formula | C8H12O4 | ||||||||||||
| Molar Mass | 172.18 | ||||||||||||
| Appearance | Liquid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Andrea Gille, et al. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 2019 Jan;20:19-27. |
Diethyl maleate
CAS: 141-05-9 F: C8H12O4 W: 172.18
Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with eth
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