| Bioactivity | Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies[1][2][3]. |
| Invitro | Dictyostatin (0-100 nM; 72-120 h) 在癌细胞中显示出抗增殖活性[2]。 Cell Viability Assay[2] Cell Line: |
| In Vivo | Dictyostatin (0.3、1 mg/kg；腹腔注射；每周一次，持续 3 个月) 可改善小鼠的 MT 密度并减少轴突营养不良[3]。 Animal Model: |
| Name | Dictyostatin |
| CAS | 156312-07-1 |
| Formula | C32H52O6 |
| Molar Mass | 532.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. George R. Pettit, et al. Isolation and structure of the cancer cell growth inhibitor dictyostatin 1. J. Chem. Soc., Chem. Commun., 1995, 2373-2670. [2]. Vollmer LL, et al. A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. Mol Cancer Ther. 2011 Jun;10(6):994-1006. [3]. Makani V, et al. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathol Commun. 2016 Sep 29;4(1):106. |