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Dictyostatin

Bioactivity Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies[1][2][3].
Invitro Dictyostatin (0-100 nM; 72-120 h) 在癌细胞中显示出抗增殖活性[2]。 Cell Viability Assay[2] Cell Line:
In Vivo Dictyostatin (0.3、1 mg/kg;腹腔注射;每周一次,持续 3 个月) 可改善小鼠的 MT 密度并减少轴突营养不良[3]。 Animal Model:
Name Dictyostatin
CAS 156312-07-1
Formula C32H52O6
Molar Mass 532.75
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. George R. Pettit, et al. Isolation and structure of the cancer cell growth inhibitor dictyostatin 1. J. Chem. Soc., Chem. Commun., 1995, 2373-2670. [2]. Vollmer LL, et al. A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. Mol Cancer Ther. 2011 Jun;10(6):994-1006. [3]. Makani V, et al. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathol Commun. 2016 Sep 29;4(1):106.

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