| Bioactivity | Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation[1][2][3]. | ||||||||||||
| Invitro | Deoxynyboquinone (DNQ; 72h) potently induces the death of cancer cells (SK-MEL-5, MCF-7, HL-60, HL-60/ADR) in culture, with IC50 values between 16 and 210 nM[2].Deoxynyboquinone is still able to induce cancer cell death under hypoxic conditions (HeLa cell; IC50: 5.1 μM)[2].Deoxynyboquinone (group B1; 0.5 μM; 3, 6, 24 hours) potently induces apoptosis in cancer cell lines (MCF-7, HL-60) through cytochrome c release[3]. | ||||||||||||
| Name | Deoxynyboquinone | ||||||||||||
| CAS | 96748-86-6 | ||||||||||||
| Formula | C15H12N2O4 | ||||||||||||
| Molar Mass | 284.27 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
Deoxynyboquinone
CAS: 96748-86-6 F: C15H12N2O4 W: 284.27
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in c
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.