| Bioactivity | Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities[2]. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain[3]. | ||||||||||||
| Invitro | Dehydrocorydaline hydroxy (0-200 μM) 处理以剂量依赖性方式显着抑制 MCF-7 细胞的生长。200 μM Dehydrocorydaline hydroxyl 处理 24 小时后，细胞活力降低了约 40%[1]。Dehydrocorydaline hydroxyl (0-200 μM) 剂量依赖性地增加 Bax 蛋白表达并降低 Bcl-2 蛋白表达[1]。Dehydrocorydaline hydroxyl (0-200 μM) 诱导 caspase-7,-8 的激活和 PARP 的裂解而不影响 caspase-9[1]。 | ||||||||||||
| In Vivo | Dehydrocorydaline hydroxy 表现出低急性毒性，小鼠口服的 LD50 约为 277.5±19.0 mg/kg 体重，腹腔注射为 21.1±1.4 mg/kg[4]。 | ||||||||||||
| Name | Dehydrocorydaline (hydroxyl) | ||||||||||||
| Formula | C22H25NO5 | ||||||||||||
| Molar Mass | 383.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85. [2]. Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14(4):3029-36. [3]. Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17(1):244. [4]. Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129. |
Dehydrocorydaline (hydroxyl)
CAS: F: C22H25NO5 W: 383.44
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activate
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