| Bioactivity | Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor[1][2][4][5]. |
| Invitro | Daunorubicin (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells[2].Daunorubicin (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells[3][4].Daunorubicin (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells[4].Daunorubicin (0.4 μM, 120 min) induces ROS generation in L3.6 cells[4].Daunorubicin (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line)[6]. Cell Viability Assay[3][4] Cell Line: |
| Name | Daunorubicin |
| CAS | 20830-81-3 |
| Formula | C27H29NO10 |
| Molar Mass | 527.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Daunorubicin
CAS: 20830-81-3 F: C27H29NO10 W: 527.52
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and
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