| Bioactivity | Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4]. | ||||||||||||
| Invitro | Daphnetin (7,8-dihydroxycoumarin) (0-40 µg/mL; 24-48 hours) inhibits the proliferation of ovarian cancer cells[1].Daphnetin (7,8-dihydroxycoumarin) (0-40 µg/mL; 24 hours; A2780 cells) induces apoptosis and increases ROS production in a dose-dependent manner[1].Daphnetin (7,8-dihydroxycoumarin) (0-40 µg/mL; 24 hours; A2780 cells) induces autophagy through modulation of the AMPK/Akt/mTOR pathway[1].Daphnetin (7,8-dihydroxycoumarin) (1-10 μM; plasmodium falciparum) exhibits schizontocidal activity in a dose-dependent manner[3]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Daphnetin | ||||||||||||
| CAS | 486-35-1 | ||||||||||||
| Formula | C9H6O4 | ||||||||||||
| Molar Mass | 178.14 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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