| Bioactivity | DPQ is a potent PARP-1 inhibitor. DPQ can reduce the N-methyl-d-aspartate (NMDA)-induced PARP activation, restoring ATP to near control levels and significantly attenuating neuronal injury in the severe NMDA exposure model. DPQ can be used for researching neuroprotection[1]. | ||||||||||||
| Target | PARP-1 | ||||||||||||
| Name | DPQ | ||||||||||||
| CAS | 129075-73-6 | ||||||||||||
| Formula | C18H26N2O2 | ||||||||||||
| Molar Mass | 302.41 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Meli E, et al. Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci. 2004;25(1):172-180. |