| Bioactivity | DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[1][2]. | ||||||||||||
| Invitro | DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC50=0.85 nM for ERβ; EC50=66 nM for ERα)[1].DPN (10 nM) prevents morphological alterations from Aβ1-42 (10 μM)-induced toxicity in cultured cortical neurons[2].DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner[2].DPN (0.1-100 nM) significantly reduces Aβ1-42-stimulated expression of Bax in a non-dose dependent manner[2].DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ1-42 treatment on cultured cortical neurons[2].DPN (0.1-100 nM) suppresses the Aβ1-42-upregulated phosphorylation of JNK and p38[2]. | ||||||||||||
| Name | DPN | ||||||||||||
| CAS | 1428-67-7 | ||||||||||||
| Formula | C15H13NO2 | ||||||||||||
| Molar Mass | 239.27 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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