| Bioactivity | DAD dichloride is a type of ion channel blocker that blocks voltage-gated potassium channels. DAD dichloride is a third-generation photoswitch that responds to visible light. DAD dichloride has the potential for restoring visual function[1]. |
| Invitro | DAD is not permanently charged, and the uncharged form enables the photoswitch to rapidly and effectively cross biological barriers and thereby access and photosensitize retinal neurons. DAD selectively photosensitizes retinal neurons upstream of retinal ganglion cells (RGCs). DAD is capable of restoring retinal ganglion cell light responses to blue or white light[1]. |
| In Vivo | Intravitreal injection of DAD restores retinal light responses and light-driven behavior to blind mice. DAD acts upstream of retinal ganglion cells, primarily conferring light sensitivity to bipolar cells. DAD is capable of generating ON and OFF visual responses in the blind retina by utilizing intrinsic retinal circuitry[1]. |
| Name | DAD dichloride |
| Formula | C26H42Cl2N6O |
| Molar Mass | 525.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Laura Laprell, et al. Photopharmacological Control of Bipolar Cells Restores Visual Function in Blind Mice. J Clin Invest. 2017 Jun 30;127(7):2598-2611. |