D-erythro-Sphingosine hydrochloride_product_DataBase

Bioactivity

D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation[1][2].

Invitro

Extracellular application of D-erythro-Sphingosine (20 μM) induces an increase in [Ca2+]i in TRPM3-transfected HEK293 cells within 20 to 30 s after start of application, whereas nontransfected control cells (NT) shows only very small responses[1].D-erythro-Sphingosine (10 μM) induces currents through TRPM3[1].Induction of retinoblastoma protein dephosphorylation by D-erythro-Sphingosine (500 nM; 24 h) precede inhibition of growth and a specific arrest in the G0/G1 phase of the cell cycle[2].

Name

D-erythro-Sphingosine hydrochloride

CAS

2673-72-5

Formula

C18H38ClNO2

Molar Mass

335.95

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Grimm C, et al. Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. Mol Pharmacol. 2005 Mar;67(3):798-805. [2]. Chao R, et al. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25;267(33):23459-62.

PeptideDB

D-erythro-Sphingosine hydrochloride

CAS: 2673-72-5 F: C18H38ClNO2 W: 335.95