| Bioactivity | Cypate is a near-infrared fluorescent dye that belongs to the family of photosensitizers. Cypate has high photostability and optical properties, and is often used in near-infrared optical imaging, as well as optical imaging, tumor marking, and drug delivery. In addition, Cypate is also used as a molecular probe and combined with targeting molecules (such as CBT or small interfering RNA) to achieve efficient detection and imaging of specific cells or tissues[1][2]. |
| Invitro | 在研究中，Cypate 偶联 upconversion 纳米颗粒 (UCNP-cy)，而装载具有抗热休克蛋白 70 (UCNP-cy-siRNA) 的小干扰 RNA 基因，可导致靶向细胞的损伤和抗肿瘤效果[1]。Cypate 还可偶联 CBT (Cysteine-containing Peptide Backbone Tag)，可用于追踪、标记和成像特定生物分子或细胞。例如，Cypate-CBT，作为近红外光声 (PA) 探针，可用于特异性成像和实时跟踪 CTSB 过表达细胞和肿瘤中的组织蛋白酶 B (CTSB) 活性。Cypate-CBT 进入 CTSB 过表达细胞后，它经历谷胱甘肽还原和 CTSB 裂解，生成 cypate 纳米粒子 Cypate-CBT-NPs，增强了肿瘤部位 PA 信号的强度和保留时间。Cypate-CBT 有潜力被用作早期癌症临床诊断的有效 PA 显像剂[2]。 |
| Name | Cypate hydrochloride |
| Formula | C41H41ClN2O4 |
| Molar Mass | 661.23 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Wang L, et al. Cypate-conjugated porous upconversion nanocomposites for programmed delivery of heat shock protein 70 small interfering RNA for gene silencing and photothermal ablation[J]. Advanced Functional Materials, 2016, 26(20): 3480-3489. [2]. Wang C, et al. Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202114766. |
Cypate hydrochloride
CAS: F: C41H41ClN2O4 W: 661.23
Cypate is a near-infrared fluorescent dye that belongs to the family of photosensitizers. Cypate has high photostability
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