| Bioactivity | Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1][2][3]. |
| Invitro | cADPR (20 nM) elicits a large rapid Ca2+ release in sea urchin eggs homogenates[1].cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes[4].cADPR (100 µM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture[5]. |
| Name | Cyclic ADP-ribose ammonium |
| Formula | C15H21N5O13P2.xNH3 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Cyclic ADP-ribose ammonium
CAS: F: C15H21N5O13P2.xNH3 W:
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized fr
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.