| Bioactivity | Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB)[1]. |
| Invitro | Cyclic AC253 (0-10 μM) 可保护神经元细胞 HFN 和 N2a 免受 Aβ1-42 诱导的细胞毒性和细胞凋亡 (apoptosis)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Cyclic AC253 相关抗体: |
| In Vivo | Cyclic AC253 (200 μg/kg，腹腔注射，每周 3 次，持续 10 周) 可提高 TgCRND8 小鼠模型的认知缺陷[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Sequence | Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2 (Disulfide bridge: Cys1-Cys26) |
| Shortening | CLGRLSQELHRLQTYPRTNTGSNTYC-NH2 (Disulfide bridge: Cys1-Cys26) |
| Formula | C126H202N42O40S2 |
| Molar Mass | 3009.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Soudy R, et al., Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease. Alzheimers Dement (N Y). 2016 Dec 10;3(1):44-56. |