| Bioactivity | Bis(cyclohexanone) Oxalyldihydrazone, a copper chelator, can be used to coordinate Copper(II) to form an intensely coloured blue copper-cuprizone complex. The cuprizone reaction has been employed in colourimetric tests for the presence of trace lev | ||||||||||||
| In Vivo | Cuprizone (0.5 mg/100 mg of diet and water given ad lib; p.o.) produces severe status spongious in the CNS, most prominently in the brain stem and cerebellar white matter of mice[1]. | ||||||||||||
| Name | Cuprizone | ||||||||||||
| CAS | 370-81-0 | ||||||||||||
| Formula | C14H22N4O2 | ||||||||||||
| Molar Mass | 278.35 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Suzuki K, et al. Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). Am J Pathol. 1969 Feb;54(2):307-25. [2]. Sanadgol N, et al. Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis. 2018 Feb;33(1):27-37. [3]. M Jake Pushie, et al. Synthesis and structural characterization of copper-cuprizone complexes. Dalton Trans. 2022 Jun 29. [4]. Haiyun Xu, et al. Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics. Front Behav Neurosci. 2010 Mar 18;4:8. |