| Bioactivity | Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules. | ||||||
| In Vivo | Corn oil-gavaged rats have 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increase in situ MNCL cell proliferation to rates observed in water-gavaged animals[1]. Corn oil is commonly used as a feed additive or a delivery vehicle for lipophilic substances In an animal research setting[3].Corn oil can become contaminated and cause death/systemic infections several days after IP injections, so corn oil should be aliquoted and frozen (recommendation); thaw and make fresh solution each time.Corn oil is more recommended for gavage administration[4].Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages[5]. Animal Model: | ||||||
| Name | Corn oil | ||||||
| CAS | 8001-30-7 | ||||||
| Appearance | Oil | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
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| Reference | [1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9. [2]. Gilbertson JR, et al. Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. Oncology. 1977;34(2):62-4. [3]. Jennifer S Hubbard, et al. Effects of Repeated Intraperitoneal Injection of Pharmaceutical-grade and Nonpharmaceutical-grade Corn Oil in Female C57BL/6J Mice. J Am Assoc Lab Anim Sci. 2017 Nov 1;56(6):779-785. [4]. Administration Of Drugs and Experimental Compounds in Mice and Rats [5]. Elisenda Alsina-Sanchis, et al. Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages. Mol Cancer Res. 2021 Feb;19(2):288-300. |