| Bioactivity | Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2]. | |||||||||
| Invitro | Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin[1].Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells[1].Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells[1].Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells[2].Conophylline inhibits DNA synthesis induced by serum[2].Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells[2]. Apoptosis Analysis[2] Cell Line: | |||||||||
| Name | Conophylline | |||||||||
| CAS | 142741-24-0 | |||||||||
| Formula | C44H50N4O10 | |||||||||
| Molar Mass | 794.89 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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Conophylline
CAS: 142741-24-0 F: C44H50N4O10 W: 794.89
Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a diff
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