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Bioactivity |
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5]. |
Invitro |
Concanamycin A can come from S. diastatochromogenes 545, as a microbial metabolite with immunomodulatory activity[1].Concanamycin A (100 nM; 0-20 h) results DNA fragmentation in CD4+ and selectively induces CD8+ T cells rapid cell death between normal and the immunized mice source, while CD8+ population in mice immunized is more sensitive[2].Concanamycin A (3-50 nM; 16 h) inhibits LPS-induced NO production in elicited peritoneal macrophages, but (25 nM; 7 h) doesn’t inhibit LPS-induced TNF-α production[3].Concanamycin A (0.01 nM-1 nM) inhibits the acidification of rat liver lysosomes (IC50 =0.061 nM), and inhibits oleate incorporation into cholesteryl ester (IC50 =14 nM)[4]. Cell Viability Assay[2] Cell Line: |
Name |
Concanamycin A |
CAS |
80890-47-7 |
Formula |
C46H75NO14 |
Molar Mass |
866.09 |
Transport |
Room temperature in continental US; may vary elsewhere. |
Storage |
Powder |
-20°C |
3 years |
In solvent |
-80°C |
6 months |
|
-20°C |
1 month |
|