| Bioactivity | Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5]. | |||||||||
| Invitro | Concanamycin A can come from S. diastatochromogenes 545, as a microbial metabolite with immunomodulatory activity[1].Concanamycin A (100 nM; 0-20 h) results DNA fragmentation in CD4+ and selectively induces CD8+ T cells rapid cell death between normal and the immunized mice source, while CD8+ population in mice immunized is more sensitive[2].Concanamycin A (3-50 nM; 16 h) inhibits LPS-induced NO production in elicited peritoneal macrophages, but (25 nM; 7 h) doesn’t inhibit LPS-induced TNF-α production[3].Concanamycin A (0.01 nM-1 nM) inhibits the acidification of rat liver lysosomes (IC50 =0.061 nM), and inhibits oleate incorporation into cholesteryl ester (IC50 =14 nM)[4]. Cell Viability Assay[2] Cell Line: | |||||||||
| Name | Concanamycin A | |||||||||
| CAS | 80890-47-7 | |||||||||
| Formula | C46H75NO14 | |||||||||
| Molar Mass | 866.09 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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Concanamycin A
CAS: 80890-47-7 F: C46H75NO14 W: 866.09
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor
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