| Bioactivity | Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450[2]. | ||||||||||||
| Invitro | Climbazole (20 µM; 48 hours) significantly decreases exosome secretion in aggressive prostate cancer (PCa) cells[1].Climbazole (20 µM) significantly inhibits the protein concentration of Alix, and Rab27a but not nSMase2[1].Climbazole is a potent inhibitor of exosome biogenesis and/or secretion[2]. | ||||||||||||
| Name | Climbazole | ||||||||||||
| CAS | 38083-17-9 | ||||||||||||
| Formula | C15H17ClN2O2 | ||||||||||||
| Molar Mass | 292.76 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161. [2]. Y Kobayashi, et al. Climbazole is a new potent inducer of rat hepatic cytochrome P450. J Toxicol Sci. 2001 Aug;26(3):141-50. |
Climbazole
CAS: 38083-17-9 F: C15H17ClN2O2 W: 292.76
Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450
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