| Bioactivity | Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways[1][2]. |
| Invitro | Cimiside E (30-90 μM; 24 h) 阻滞细胞周期，诱导 ASG 细胞凋亡[1]。Cimiside E (30-90 μM; 12-48 h) 对 AGS 细胞有较强的细胞毒性，并表现出抗增殖活性[1]。Cimiside E (15-60 μM; 6-24 h) 诱导 ASG细胞中 DNA 片段化，(30-60 μM; 1-6 h) 并在 3 h 时激活 FasL 的表达，在 1 h 激活 Fas[1]。Cimiside E (30-90 μM; 3-24 h) 介导 caspase 级联，增加 Bax/Bcl-2 比值，降低突变型 p53 和 procaspase 3 蛋白水平[1]。 Western Blot Analysis[1] Cell Line: |
| Name | Cimiside E |
| CAS | 154822-57-8 |
| Formula | C35H54O8 |
| Molar Mass | 602.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guo LY, et al. Cimiside E arrests cell cycle and induces cell apoptosis in gastric cancer cells. Arch Pharm Res. 2009 Oct;32(10):1385-92. [2]. Jamróz MK, et al. One new and six known triterpene xylosides from Cimicifuga racemosa: FT-IR, Raman and NMR studies and DFT calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jul;93:10-8. |