| Bioactivity | Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2)4 G4 with a Kd value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS)[1]. |
| Invitro | Chrexanthomycin C (Compounds cC) (0.1-10 mM) binds DNA (G4C2)4 G4 with a Kd value of 2.8 mM[1].Chrexanthomycin C has good permeability, low cytotoxicity, and nonhemolytic activity[1].Chrexanthomycin C (1.57 μM) rescues G4C2 EHR-related pathologies in cells[1].Chrexanthomycin C selectively binds to DNA and RNA G4C2 G4s[1]. Chrexanthomycin C (0-100 μM) dramatically reduceS G4C2 EHR-caused cell death, diminish G4C2 RNA foci in (G4C2)29-expressing Neuro2a cells, and significantly eliminate ROS in HT22 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | Chrexanthomycin C |
| Formula | C31H24O15 |
| Molar Mass | 636.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |