Cholest-5-ene-3ß,22(S)-diol_product_DataBase

Bioactivity	Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2].
Invitro	Cholest-5-ene-3ß,22(S)-diol (10 μg/mL, 20 μg/mL; 24 h) 对 U937 细胞磷脂酰丝氨酸外化、线粒体跨膜电位、细胞对碘化丙啶的通透性和细胞核形态变化无影响[1]。
In Vivo	Cholest-5-ene-3ß,22(S)-diol (30 mg/kg; 口服; 在加饮食中，共处理 3 周) 减少体重增加，消除高脂饮食引起的血清中三酰甘油 (TAG) 水平的增加[2]。在大鼠中的药代动力学分析[2]Route
Name	Cholest-5-ene-3ß,22(S)-diol
CAS	22348-64-7
Formula	C27H46O2
Molar Mass	402.65
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lemaire-Ewing S, et al. Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol. 2005 Mar;21(2):97-114. [2]. Tranheim Kase E, et al. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids. 2012 May;47(5):483-93.

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